A. Introduction

1.

The Central Nervous System consists of the brain and the spinal cord. The brain is contained (and protected) in the skull while the spinal cord is located in and protected by the vertebral column.

2.
The brain itself consists of the following components:
  1. The cerebrum (large brain)
  2. The cerebellum (small brain)
  3. The truncus cerebri (brain stem)
B. The Brain (Cerebrum)
1.
We will first discuss the various parts of the cerebrum. This is not an easy matter as the brain consists of several regions, each with a special function.
2.
Because of all these functions, these regions have special names (which you will have to remember!).

3.

Let’s start with the major regions. As you can see in the picture, the front (anterior) part of the brain consists of the frontal region (also called frontal lobe). This is our cognitive region (memory, emotions, social interaction, motor control, etc).

4.
Behind the frontal lobe is the parietal lobe. This centre collects information from several sensors such as touch and the position and movements of our body such as our arms, legs etc.
5.
Below the frontal and the parietal lobe is the temporal lobe. This lobe processes information from our sensors (ears, processing emotions, storing and retrieving memories).
6.
The occipital lobe, at the back of the brain, is the area where our visual information (obtained from the eyes) is processed, such as depth, colour, object and face determination and memory (again!).

7.

In the adjoining diagram, you can now see the brain from above (= cranial). This shows that we have actually two brains; one right and one left!  So, we actually have two frontal lobes, two temporal lobes etc!

C. Brain stem, cerebellum, spinal cord
1.
Below the brain (cerebrum) there are three additional structures:
  1. the brain stem
  2. the cerebellum
  3. the spinal cord
2.
The brain stem is the structure that connects the brain (cerebrum) with the cerebellum and the spinal cord.
3.
The cerebellum plays a major role in the regulation of our movements (= motor control) together with balance control (you don’t want to lose your balance!).

4.

The spinal cord is a huge relay station connecting our body, through the peripheral nervous system, to our brain (cerebrum, cerebellum and brainstem) (see panel F)

5.

In addition, we also have the entry or exit points of quite a number of cranial nerves. On the diagram are shown:

  1. the olfactory (nose) tract
  2. the optical chiasm (the start of the optical nerve)
D. Middle Brain

1.

After having seen the brain from the side, from above and from below, now is the time to cut the brain in half and see how it looks inside!

2.
Most of the structures seen from above or outside are also visible in this cross-section.
3.
But at the ‘bottom’ of most lobes, there is a structure called ‘corpus callosum’, which, in turn, surrounds an internal area, in the middle of the brain.
4.
The corpus callosum is an area where …
5.
In the middle of the brain, there are numerous other centres as described in the next picture.
6.
In a sense, the most important one is the presence of a space! The ventricles, which are filled with fluid. Adjacent to the ventricles are areas such as the thalamus, the hypothalamus, the mammillary body and the fornix. All these will be discussed at length in the Autonomous Nervous System (ref).
E. Ventricular System

1.

The brain must be kept alive at all costs! There are several systems that provide the brain and the brain cells with oxygen, nutrients etc. The most important one is of course the blood circulation (which will be discussed later).

2.
But there are additional systems and one of them is the liquor cerebrospinal system. But for this system, several cavities and channels mut be present in the central nervous system.
3.
This system is termed the ventricular system (not be confused with the ventricles in the heart!).
4.
The ventricular system consists of four ventricles (cavities) that are connected to each other:
  1. Two lateral ventricles in the cerebrum (left and right)
  2. A third ventricle located in the upper brainstem
  3. A fourth ventricle located in the lower brainstem

5.

These ventricles are connected through several canals. Below the fourth ventricle, starts the central canal that runs all the way down the spinal cord.

6.

The liquor itself is produced by special cells located mostly in the wall of the fourth ventricle. From there it flows through the other cavities and through the arachnoidal space into the sinus sagittal, located in the dura matter which surrounds the brain.

7.
The main function of the cerebrospinal liquor is to provide a fluid ‘shell’ around the cerebrum in which the brain can ‘float’. This is important as it protects the brain tissue from internal damage when the skull is being hit by an object.
8.

The second purpose of the liquor is to drain metabolic products from the brain tissue to the lymph circulation. Approximately 0,5 l liquor is being produced every day.

F. The Spinal Cord
1.
Finally, we also need, in this introduction, to discuss the basics of the spinal cord.
2.
As you may know, the spinal cord is where all the nerves run from the brain to the rest of the body or from the body back to the brain.
3.
But it is not just a bundle of wires as in a telephone cable! It is much more organized which we will discuss, in some detail, here.
4.
In this cross-section of the spinal cord, you may notice two different shades of ‘grey’ on its surface; the ‘white matter’ and the ‘grey matter’.
5.
The grey matter, in the centre of the cord, consists mainly of the soma of the nerves; the cell bodies. Surrounding this grey matter, is the white matter, which is mainly caused by the myelin-sheath surrounding the nerve cables.
6.
Remember the myelin-sheath? This is a sheath or a sleeve that surrounds and isolated an axon from its neighbours and thereby also increases the propagation of the action potentials in the axons (see A.3.5. Saltatory Propagation)

7.

Since there are a lot of these ‘cables’ (= axons) running up or down the spinal cord, this are mostly located surrounding the central zone which makes this area more ‘whitish’.

8.
Also note that from this white matter, some of these nerves may leave the spinal cord through the anterior roots to the body. These are usually motor nerves that will stimulate a neighbouring muscle.
9.
On the other side of the roots are the posterior roots, which is the entry point for the sensory nerves, that conduct sensory information from various parts of the body to the brain.
Slides